Glutamatergic propagation of GABAergic seizure-like afterdischarge in the hippocampus in vitro.

Afterdischarge in the Hippocampus In Vitro Glutamatergic Propagation of GABAergic Seizure-Like

Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons.

A variety of epileptic seizure models have shown that activation of glutamatergic pyramidal cells is usually required for rhythm generation and/or synchronization in hippocampal seizure-like oscillations in vitro. However, it still remains unclear whether GABAergic interneurons may be able to drive the seizure-like oscillations without glutamatergic transmission. Here, we found that electrical ...

Comparable GABAergic mechanisms of hippocampal seizure-like activity in post-tetanic and low-Mg conditions

It is known that GABA is a major inhibitory neurotransmitter in mature mammalian brains, but the effect of this substance is sometimes converted into depolarizing or even excitatory when the postsynaptic Cl concentration becomes high. Recently we have shown that seizure-like afterdischarge induced by tetanic stimulation in normal extracellular fluid (post-tetanic afterdischarge) is mediated thr...

Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity.

It has recently been shown that electrical stimulation in normal extracellular fluid induces seizure-like afterdischarge activity that is always preceded by GABA-dependent slow depolarization. These afterdischarge responses are synchronous among mature hippocampal neurons and driven by excitatory GABAergic input. However, the differences in the mechanisms whereby the GABAergic signals in pyrami...

Septo-Hippocampo-Septal Loop and Memory Formation

The Cholinergic and GABAergic .bers of the medial septal/diagonal band of Broca (MS/DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. The activity of septal and hippocampal neuron...